NEFH Antibody

ArtNr	OAEE00501
Hersteller	AVIVA Systems Biology
Menge	0.1 mg (C100)
Kategorie	Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Antibodies Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining Neurodegeneration Markers Glial Cell Markers
Typ	Antibody Monoclonal
Applikationen	WB, IHC, ELISA
Clon	NF-05
Specific against	Human (Homo sapiens), Rat (Rattus norvegicus), Pig (Porcine, Sus scrofa domesticus)
Host	Mouse
Isotype	IgG1
Citations	Porchet R, Probst A, Draberova E, Draber P, Riederer IM, Riederer BM: Differential subcellular localization of phosphorylated neurofilament and tau proteins in degenerating neurons of the human entorhinal cortex.Neuroreport. 2003 May 23;14(7):929-33. Cote F, Collard JF, Julien JP: Progressive neuronopathy in transgenic mice expressing the human neurofilamentheavy gene: a mouse model of amyotrophic lateral sclerosis. Cell. 1993 Apr 9;73(1):35-46. Ohara O, Gahara Y, Miyake T, Teraoka H, Kitamura T:Neurofilament deficiency in quail caused by nonsense mutation in neurofilament-L gene. J Cell Biol. 1993 Apr;121(2):387-95. Brown RH Jr.: Amyotrophic lateral sclerosis: recent insights from genetics and transgenic mice. Cell. 1995 Mar 10;80(5):687-92. Petzold A, Keir G, Warren J, Fox N, Rossor MN: A systematic review and meta-analysis of CSF neurofilament protein levels as biomarkers in dementia. Neurodegener Dis. 2007;4(2-3):185-94. Miyazawa I, Nakashima I, Petzold A, Fujihara K, Sato S, Itoyama Y: High CSF neurofilament heavy chain levels in neuromyelitis optica. Neurology. 2007 Mar 13;68(11):865-7. Wild EJ, Petzold A, Keir G, Tabrizi SJ: Plasma neurofilament heavy chain levels in Huntington's disease.Neurosci Lett. 2007 May 7;417(3):231-3.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	200 kDa neurofilament protein;CMT2CC;neurofilament heavy polypeptide;neurofilament triplet H protein;neurofilament,heavy polypeptide 200kDa;NFH;NF-H.
Similar products	Neurofilament heavy protein
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Applications	Enzyme-linked immunosorbent assay\|Immunohistochemistry-Frozen\|Western blot
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Manufacturer - Application Additional Information	WB: Recommended dilution: 1 ug/mL. Positive Control: Lysate of brain homogenate.ELISA: Capture antibody
Gene symbol	NEFH
Gene Fullname	neurofilament heavy chain
Product format	Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Reconstitution and storage	2°C to 8°C
Description of target	Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins.
Nucleotide accession_num	NM_021076.3
Protein accession_num	NP_066554.2
Protein name	Neurofilament heavy polypeptide
Clonality	Monoclonal
Purification	Purified
Immunogen	Pig brain neurofilament protein-enriched fraction after depolymerization of microtubules
Manufacturer - Specificity	The antibody NF-05 recognizes a nonphosphorylated epitope of neurofilament heavy protein (NF-H), a 210 kDa intracellular structural protein of Intermediate Filament Proteins family. NF-H is mainly expressed in the central and peripheral nervous system and reproductive system and is biochemically very stable.
Concentration	1 mg/ml

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Menge: 0.1 mg (C100)

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