Anti-Syntaxin 1A

ArtNr	OAPC00068
Hersteller	AVIVA Systems Biology
Menge	100 ul
Kategorie	Oncology Neuroscience Molecular Targets for Neuroscience Neural Signaling Antibodies By Cell Type Carcinoma Cell Biology Cell Status Apoptosis Immunohistochemistry Western Blot Primary Antibodies
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	WB, IHC
Clon	SP8
Specific against	Human (Homo sapiens), Rat (Rattus norvegicus), Pig (Porcine, Sus scrofa domesticus)
Host	Mouse
Isotype	IgG1
Citations	Khvotchev M, Dulubova I, Sun J, Dai H, Rizo J, SÃƒÂ¼dhof TC (2007) Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus. J Neurosci. 2007 Nov 7;27(45):12147-55 Castillo MA, Ghose S, Tamminga CA, Ulery-Reynolds PG (2010) Deficits in syntaxin 1 phosphorylation in schizophrenia prefrontal cortex. Biol Psychiatry. 67(3):208-16 Honer, W. G., Hu, L. & Davies, P. Human synaptic proteins with a heterogeneous distribution in cerebellum and visual cortex. Brain Research 609, 9-20 (1993).
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	STX1,HPC-1,P35-1,SYN1A
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Monoclonal Antibodies/Pan Specific, Root Catalog/Products/Primary Antibodies
Manufacturer - Isotype	IgG¹
Shipping Temperature	Wet Ice
Molecular Weight	~36kDa
Manufacturer - Application Additional Information	The antibody has been directly tested for reactivity in human, rat, pig, and hamster. Western blot of rat cortex lysate showing specific immunolabeling of the ~ 36k syntaxin 1A protein.
Gene symbol	STX1A
Product format	Liquid. 100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.
Reconstitution and storage	Store at -20C; stable for at least one year.
Description of target	Syntaxins are a family of proteins involved in the docking of synaptic vesicles with the plasma membrane. Syntaxin, along with synaptobrevin and SNAP-25, forms the SNARE complex which mediates synaptic vesicle fusion and exocytosis. Binding of Munc18-1 to the N-terminus of syntaxin 1 has been demonstrated to be essential for exocytic membrane fusion (Khvotchev et al., 2007). Decreased levels of phosphorylated syntaxin 1 in the prefrontal cortex have recently been correlated with schizophrenia (Castillo et al., 2010).
Protein accession_num	NP_001159375.1
Protein name	Syntaxin-1A
Clonality	Monoclonal
Purification	Protein G purified culture supernatant.
Immunogen	Synaptic immunoprecipitate (crude) from human brain.
Homology	Human; Pig; Rat
Manufacturer - Specificity	The antibody is specific for the ~ 36 kDa syntaxin protein in Western blots of rat brain lysate. The antibody has also been used for immunohistochemistry on formalin fixed, vibratome sections. Does not work on paraffin sections.

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