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Anti-Alpha-Internexin (NF66) (OAPC00002)

ArtNr OAPC00002
Hersteller AVIVA Systems Biology
Menge 100 ul
Kategorie
Typ Antibody Monoclonal
Format Liquid containing 10 mM sodium azide.
Applikationen WB, IF, IHC
Clon 1D2
Specific against Mammal
Host Mouse
Isotype IgG1
ECLASS 10.1 42030590
ECLASS 11.0 42030590
UNSPSC 12352203
Lieferbar
Gene symbol
INA
Protein name
Alpha-internexin
Molecular weight
ca.66kDa
Product format
Liquid containing 10 mM sodium azide.
Gene id
24503
Reconstitution and storage
Store at -20C in undiluted aliquots; stable for at least 1 year. Avoid freeze/thaw cycles.
Description of target
Alpha-internexin is a Class IV intermediate filament originally discovered as it co-purifies with other neurofilament subunits (1). Alpha-internexin is related to but distinct from the better known neurofilament triplet proteins, NF-L, NF-M and NF-H, having similar protein sequence motifs and a similar intron organization. It is expressed only in neurons and in large amounts early in neuronal development, but is down-regulated in many neurons as development proceeds. Many classes of mature neurons contain alpha-internexin in addition to NF-L, NF-M and NF-H. In some mature neurons alpha-internexin is the only neurofilament subunit expressed. Antibodies to alpha-internexin are therefore unique probes to study and classify neuronal types and follow their processes in sections and in tissue culture. In addition, recent studies show a marked up-regulation of alpha-internexin during neuronal regeneration (2). The use of antibodies to this protein in the study of brain tumors has not been examined to date, but is likely to be of interest. Recently Cairns et al. used this antibody to show that alpha-internexin is an abundant component of the inclusions of neurofilament inclusion body disease (NFID), a serious human neurodegenerative disorder (3, 4). The antibody was also used to confirm the presence of circulating auto-antibodies to alpha-internexin in the sera of some patients with endocrine autoimmunity, as well as in some normal individuals (5).
Homology
Most mammals
Purification
Total IgG fraction
Clonality
Monoclonal
Immunogen
Recombinant rat alpha-internexin expressed in and purified from E. coli.
Drywet
Wet Ice

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Menge: 100 ul
Lieferbar: In stock
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