GPR56 Antibody

ArtNr	OAAB18677
Hersteller	AVIVA Systems Biology
Menge	400 ul
Kategorie	Oncology Neuroscience Metabolism Diabetes Cholesterol & Lipid Metabolism Targets for Rodent Neurosciences Neural Signaling Antibodies By Cell Type Carcinoma Melanoma Cell Biology Cell Culture Cytokines Adenocarcinoma Cytoskeleton Western Blot ELISA Immunofluorescence Primary Antibodies By Organ Bladder Cancer Hepatic Cancer small GTPases Rho Subfamily
Typ	Antibody Monoclonal
Applikationen	WB
Clon	1443CT377.65.29
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1 Kappa
Citations	Liu M.,et al.Genomics 55:296-305(1999). Zendman A.J.W.,et al.FEBS Lett. 446:292-298(1999). Kaighin V.A.,et al.Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases. Clark H.F.,et al.Genome Res. 13:2265-2270(2003). Ota T.,et al.Nat. Genet. 36:40-45(2004).
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	BFPP,BPPR,GPR56,TM7LN4,TM7XN1
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Category	Root Catalog/Products/Primary Antibodies
Manufacturer - Isotype	IgG1, k
Shipping Temperature	Wet Ice
Molecular Weight	78 kDa
Manufacturer - Application Additional Information	IF: 1:25 WB: 1:1000 WB: 1:2000
Gene symbol	GPR56
Product format	Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Reconstitution and storage	Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Description of target	Involved in cell adhesion and probably in cell-cell interactions. Regulates the migration of neural precursor cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basemant membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Isoforms show differences in receptor signaling, specifically in serum response element (SRE) transcriptional activation upon overexpression. Overexpression inhibits melanoma tumor growth and metastasis and, during melanoma progression, regulates VEGFA production and angiogenesis through PRKCA; unprocessed GPR56 is inhibiting and GPR56 NT is activating angiogenesis.
Clonality	Monoclonal
Purification	This antibody is purified through a protein G column, followed by dialysis against PBS.
Immunogen	This antibody is generated from a mouse immunized with a recombinant protein.

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OAAB18677-datasheet.pdf

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Menge: 400 ul

lieferbar

Lieferung vsl. bis 30.10.2025