PRDM14 Antibody - N-terminal region (OAAB19011)

Wet Ice

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'.

This antibody is purified through a protein A column, followed by peptide affinity purification.