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AIFM1 Antibody - C-terminal region

AIFM1 Antibody - C-terminal region

ArtNr	OABB01397
Hersteller	AVIVA Systems Biology
Menge	100 ug/vial
Kategorie	Neuroscience Neural Lineage Markers Antibodies Cell Biology Cell Status Apoptosis Immunohistochemistry Western Blot ELISA Immunocytochemistry Primary Antibodies Immunostaining Microglia Markers
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	discs large homolog 4;disks large homolog 4;MRD62;post-synaptic density protein 95;Postsynaptic density protein 95;PSD95;SAP90;SAP-90;synapse-associated protein 90;Tax interaction protein 15.
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Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Gene symbol	DLG4
Gene Fullname	discs large MAGUK scaffold protein 4
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Apoptosis-inducing factor 1, mitochondrial, also known as AIF or PDCD8 is a protein that in humans is encoded by the AIFM1 gene. AIFM1 gene is mapped to Xq26.1 based on an alignment of the AIFM1 sequence with the genomic sequence. This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. A related pseudogene has been identified on chromosome 10.
Protein name	Disks large homolog 4
Clonality	Recombinant Monoclonal
Purification	Affinity Purified
Immunogen	A synthesized peptide derived from human PSD95
Dilution	Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression.

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OABB01397-datasheet.pdf

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Menge: 100 ug/vial

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Lieferung vsl. bis 25.12.2025

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