NCSTN Antibody - N-terminal region

Polyclonal Antibody

BMP4

Liquid

Nicastrin, also known asA NCSTN, is aA proteinA that is a part of the gamma secretaseA protein complex. It is mapped to 1q23.2. This gene is not catalytically active, but instead promotes the maturation and proper trafficking of the other proteins in the gamma secretaseA protein complex, all of which undergo significant post-translational modificationA before becoming active in the cell. NCSTN encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex.A The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly.A The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease. Nicastrin has also been identified as a regulator of neprilysin, anA enzymeA involved in the degradation of amyloid beta fragment.

Recombinant Monoclonal

A synthesized peptide derived from human BMP4