HDAC3 Antibody (OACA02423)

histone deacetylase 3

49 kDa

8841

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.

Caprylic Acid Ammonium Sulfate Precipitation purified

Provided in PBS, pH 7.4, 50% Glycerol, 0.03% Proclin 300

Wet Ice