STAT5B Antibody

ArtNr	OACA02429
Hersteller	AVIVA Systems Biology
Menge	100 ul
Kategorie	Oncology Neuroscience Targets for Rodent Neurosciences Antibodies By Cell Type Hematology Leukemia Lymphoma Immunohistochemistry Immunoprecipitation Western Blot ELISA Primary Antibodies CHiP Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IHC, ELISA, CHIP
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1] A Novel Missense Mutation in the SH2 Domain of the STAT5B Gene Results in a transcriptionally inactive STAT5b associated with severe IGF-I deficiency, immune dysfunction, and lack of pulmonary disease. Scaglia P.A., Martinez A.S., Feigerlova E., Bezrodnik L., Gaillard M.I., Di Giovanni D., Ballerini M.G., Jasper H.G., Heinrich J.J., Fang P., Domene H.M., Rosenfeld R.G., Hwa V. J. Clin. Endocrinol. Metab. 97:E830-839 (2012). [2] Growth hormone insensitivity associated with a STAT5b mutation. Kofoed E.M., Hwa V., Little B., Woods K.A., Buckway C.K., Tsubaki J., Pratt K.L., Bezrodnik L., Jasper H., Tepper A., Heinrich J.J., Rosenfeld R.G.N. Engl. J. Med. 349:1139-1147 (2003). [3] Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells. Chaix A., Lopez S., Voisset E., Gros L., Dubreuil P., De Sepulveda P.J. Biol. Chem. 286:5956-5966 (2011).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GHISID2;signal transducer and activator of transcription 5B;STAT5;transcription factor STAT5B.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Molecular Weight	90 kDa
Application Data	WB:1:500-2000, IHC:1:20-1:200
Gene symbol	STAT5B
Gene Fullname	signal transducer and activator of transcription 5B
Protein size	787
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Carries out a dual function: signal transduction and activation of transcription (PubMed:29844444). Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.
Nucleotide accession_num	NM_012448.3
Protein accession_num	NP_036580.2
Protein name	Signal transducer and activator of transcription 5B
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Signal transducer and activator of transcription 5B protein (40-280AA)
Homology	Human
Manufacturer - Specificity	Human
Formulation	Provided in PBS, pH 7.3, 50% Glycerol, 0.02% Sodium Azide

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