CHD1 Antibody

ArtNr	OACA02431
Hersteller	AVIVA Systems Biology
Menge	100 ul
Kategorie	Antibodies Immunohistochemistry Immunoprecipitation Western Blot ELISA Primary Antibodies CHiP Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	IHC, ELISA, CHIP
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1] The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). The MGC Project TeamGenome Res. 14:2121-2127 (2004). [2] Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains. Sims R.J. III, Chen C.-F., Santos-Rosa H., Kouzarides T., Patel S.S., Reinberg D.J. Biol. Chem. 280:41789-41792 (2005).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	ATP-dependent helicase CHD1;CHD-1;chromodomain-helicase-DNA-binding protein 1;PILBOS.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Molecular Weight	197 kDa
Manufacturer - Application Additional Information	IHC: 1:20~200
Gene symbol	CHD1
Gene Fullname	chromodomain helicase DNA binding protein 1
Protein size	1710
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity).
Nucleotide accession_num	NM_001270.2
Protein accession_num	NP_001261.2
Protein name	Chromodomain-helicase-DNA-binding protein 1
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Chromodomain-helicase-DNA-binding protein 1 protein (1501-1710AA)
Homology	Human
Formulation	Provided in PBS, pH 7.3, 50% Glycerol, 0.02% Sodium Azide
Concentration	Varies by lot. See vial for concentration.

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Menge: 100 ul

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