STK24 Antibody

ArtNr	OACA02639
Hersteller	AVIVA Systems Biology
Menge	50 ug
Kategorie	Oncology Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Neural Signaling Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Lymphoma Myeloma Melanoma Sarcoma Cell Biology Cell Status Apoptosis Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies Immunostaining Microglia Markers Glial Cell Markers
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]Cloning and characterization of a human STE20-like protein kinase with unusual cofactor requirements.Schinkmann K., Blenis J.J. Biol. Chem. 272:28695-28703(1997) [2]Identification of a human brain-specific isoform of mammalian STE20-like kinase 3 tha
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	epididymis secretory protein Li 95;HEL-S-95;mammalian STE20-like protein kinase 3;MST3;MST3B;serine/threonine kinase 24 (STE20 homolog,yeast);serine/threonine-protein kinase 24;STE20;STE20-like kinase 3;STE20-like kinase MST3;sterile 20-like kinase 3;STK3.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	STK24
Gene Fullname	serine/threonine kinase 24
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Regulates also cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.
Nucleotide accession_num	NM_001032296
Protein accession_num	NP_001027467
Protein name	Serine/threonine-protein kinase 24
Clonality	Polyclonal
Purification	Protein G Purified
Immunogen	Recombinant Human Serine/threonine-protein kinase 24 protein (1-431AA)
Formulation	50% Glycerol, 0.01M PBS, PH 7.4

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