MAS1 Antibody

ArtNr	OACA03279
Hersteller	AVIVA Systems Biology
Menge	50 ug
Kategorie	Oncology Neuroscience Molecular Targets for Neuroscience Antibodies By Cell Type Carcinoma Hematology Lymphoma Myeloma Melanoma Immunohistochemistry Western Blot ELISA Immunofluorescence Cardiovascular Research Heart Failure Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Purity	> 95%
Citations	[1]"Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS."Canals M., Jenkins L., Kellett E., Milligan G.J. Biol. Chem. 281:16757-16767(2006). [2]"G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor."Kostenis E., Milligan G., Christopoulos A., Sanchez-Ferrer C.F., Heringer-Walther S., Sexton P.M., Gembardt F., Kellett E., Martini L., Vanderheyden P., Schultheiss H.P., Walther T.Circulation 111:1806-1813(2005). [3]"The mas oncogene encodes an angiotensin receptor."Jackson T.R., Blair L.A.C., Marshall J., Goedert M., Hanley M.R.Nature 335:437-440(1988).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	MAS;MAS1 oncogene;Mas-related G protein-coupled receptor A;MGRA;proto-oncogene Mas.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Manufacturer - Application Additional Information	WB: 1:500~5000IHC: 1:20~200IF: 1:50~200
Gene symbol	MAS1
Gene Fullname	MAS1 proto-oncogene, G protein-coupled receptor
Product format	Liquid 0.01M PBS (pH 7.4) with 0.03% Proclin300 and 50% glycerol
Reconstitution and storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
Description of target	Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.
Nucleotide accession_num	NM_002377
Protein accession_num	NP_002368
Protein name	Proto-oncogene Mas
Clonality	Polyclonal
Purification	Protein G Purified
Immunogen	Recombinant Human Proto-oncogene Mas protein (285-325AA)
Formulation	50% Glycerol, 0.01M PBS, PH 7.4
Concentration	Varies by lot. See vial for concentration.

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Menge: 50 ug

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