MIB1 Antibody

ArtNr	OACA04290
Hersteller	AVIVA Systems Biology
Menge	50 ug
Kategorie	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Antibodies By Cell Type Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Apoptosis Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies By Organ Heart & Blood Cancer Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1] "Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta."Itoh M., Kim C.-H., Palardy G., Oda T., Jiang Y.-J., Maust D., Yeo S.-Y., Lorick K., Wright G.J., Ariza-McNaughton L., Weissman A.M., Lewis J., Ch
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	DAPK-interacting protein 1;DIP1;DIP-1;E3 ubiquitin-protein ligase MIB1;LVNC7;MIB;Mind bomb homolog 1;mindbomb E3 ubiquitin protein ligase 1;RING-type E3 ubiquitin transferase MIB1;ubiquitin ligase mind bomb;zinc finger ZZ type with ankyrin repeat domain protein 2;ZZANK2;ZZZ6.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	MIB1
Gene Fullname	MIB E3 ubiquitin protein ligase 1
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.
Nucleotide accession_num	NM_020774
Protein accession_num	NP_065825
Protein name	E3 ubiquitin-protein ligase MIB1
Clonality	Polyclonal
Purification	Protein G Purified
Immunogen	Recombinant Human E3 ubiquitin-protein ligase MIB1 protein (5-332AA)
Formulation	50% Glycerol, 0.01M PBS, PH 7.4

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Menge: 50 ug

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Lieferung vsl. bis 25.12.2025

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