CASP8 Antibody

ArtNr	OACA04348
Hersteller	AVIVA Systems Biology
Menge	50 ug
Kategorie	Oncology Neuroscience Metabolism Diabetes Molecular Targets for Neuroscience Aging & Neurological Disorders Neural Epigenetics Antibodies By Cell Type Carcinoma Hematology Leukemia Lymphoma Cell Biology Obesity Cell Status Necrosis Apoptosis Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Purity	> 95%
Citations	[1] Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death.Boldin M.P., Goncharov T.M., Goltsev Y.V., Wallach D.Cell 85:803-815(1996) [2] FLICE, a novel FADD-homologous ICE/CED-3-like protease, i
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	ALPS2B;apoptotic cysteine protease;apoptotic protease Mch-5;CAP4;Casp-8;caspase 8,apoptosis-related cysteine peptidase;caspase 8,apoptosis-related cysteine protease;caspase-8;FADD-homologous ICE/CED-3-like protease;FADD-like ICE;FLICE;ICE-like apoptotic protease 5;MACH;MACH-alpha-1/2/3 protein;MACH-beta-1/2/3/4 protein;MCH5;MORT1-associated ced-3 homolog.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Manufacturer - Application Additional Information	WB: 1:500~2000IHC: 1:10~100IF: 1:50~200
Gene symbol	CASP8
Gene Fullname	caspase 8
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-\|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.
Nucleotide accession_num	NM_001080124
Protein accession_num	NP_001073593
Protein name	Caspase-8
Clonality	Polyclonal
Purification	Protein G Purified
Immunogen	Recombinant Human Caspase-8 protein (217-374AA)
Formulation	50% Glycerol, 0.01M PBS, PH 7.4
Concentration	Varies by lot. See vial for concentration.

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Menge: 50 ug

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Lieferung vsl. bis 25.12.2025

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