METRNL Antibody

ArtNr	OACA05005
Hersteller	AVIVA Systems Biology
Menge	50 ug
Kategorie	Antibodies Cell Biology Cell Culture Cytokines Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IHC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Purity	> 95%
Citations	[1]"Subfatin is a novel adipokine and unlike Meteorin in adipose and brain expression." Li Z.Y., Zheng S.L., Wang P., Xu T.Y., Guan Y.F., Zhang Y.J., Miao C.Y. CNS Neurosci. Ther. 20:344-354(2014). [2]"Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis." Rao R.R., Long J.Z., White J.P., Svensson K.J., Lou J., Lokurkar I., Jedrychowski M.P., Ruas J.L., Wrann C.D., Lo J.C., Camera D.M., Lachey J., Gygi S., Seehra J., Hawley J.A., Spiegelman B.M. Cell 157:1279-1291(2014). [3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	cometin;meteorin,glial cell differentiation regulator-like;meteorin-like protein;subfatin.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Molecular Weight	34 kDa
Manufacturer - Application Additional Information	WB: 1:500~5000
Gene symbol	METRNL
Gene Fullname	meteorin like, glial cell differentiation regulator
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity).
Nucleotide accession_num	NM_001004431
Protein accession_num	NP_001004431
Protein name	Meteorin-like protein
Clonality	Polyclonal
Purification	Protein G Purified
Immunogen	Recombinant Human Meteorin-like protein (46-311AA)
Concentration	Varies by lot. See vial for exact concentration.

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OACA05005-datasheet.pdf

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Menge: 50 ug

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Lieferung vsl. bis 30.10.2025

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