DNAJB14 Antibody

ArtNr	OACA05364
Hersteller	AVIVA Systems Biology
Menge	50 ug
Kategorie	Oncology Neuroscience Neuroinflammation Protein Aggregation, Clearance & Misfolding Antibodies By Cell Type Blastoma Carcinoma Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	IF, IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Purity	>95%
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	DnaJ (Hsp40) homolog,subfamily B,member 14;dnaJ homolog subfamily B member 14;EGNR9427;PRO34683.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	DNAJB14
Gene Fullname	DnaJ heat shock protein family (Hsp40) member B14
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:24732912). Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities (PubMed:24732912). Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:27916661). When overexpressed, forms membranous structures together with DNAJB12 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear (PubMed:24732912).
Nucleotide accession_num	NM_001031723
Protein accession_num	NP_001026893
Protein name	DnaJ homolog subfamily B member 14
Clonality	Polyclonal
Purification	Protein G Purified
Immunogen	Recombinant Human DnaJ homolog subfamily B member 14 protein (1-244AA)
Formulation	50% Glycerol, 0.01M PBS, PH 7.4

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Menge: 50 ug

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Lieferung vsl. bis 25.12.2025

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