CD300LF Antibody

ArtNr	OACA05369
Hersteller	AVIVA Systems Biology
Menge	50 ug
Kategorie	Oncology Antibodies By Cell Type Blastoma Carcinoma Hematology Leukemia Lymphoma Melanoma Sarcoma Adenocarcinoma Immunohistochemistry ELISA Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]"The crystal structure of the extracellular domain of the inhibitor receptor expressed on myeloid cells IREM-1." Marquez J.A., Galfre E., Dupeux F., Flot D., Moran O., Dimasi N. J. Mol. Biol. 367:310-318(2007). [2]"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004). [3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	CD300 antigen-like family member F;CD300f;CLM1;CLM-1;CMRF35-like molecule 1;IgSF13;immune receptor expressed on myeloid cells 1;immunoglobin superfamily member 13;immunoglobulin superfamily member 13;inhibitory receptor IREM1;IREM1;IREM-1;LMIR3;NK inhibitory receptor;NKIR.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	CD300LF
Gene Fullname	CD300 molecule like family member f
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:15549731). Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands (PubMed:24035150). May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (By similarity). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:22043923). Inhibits osteoclast formation. Induces macrophage cell death upon engagement (By similarity).
Nucleotide accession_num	NM_001289082
Protein accession_num	NP_001276011
Protein name	CMRF35-like molecule 1
Clonality	Polyclonal
Purification	Protein G Purified
Immunogen	Recombinant Human CMRF35-like molecule 1 protein (20-156AA)
Formulation	50% Glycerol, 0.01M PBS, PH 7.4

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