DCUN1D1 Antibody

ArtNr	OACA05541
Hersteller	AVIVA Systems Biology
Menge	50 ug
Kategorie	Oncology Antibodies By Cell Type Carcinoma Immunohistochemistry Western Blot ELISA Primary Antibodies By Organ Skin Cancer Pancreatic Cancer Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]Initial characterization of the human central proteome. Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011). [2]SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation. Kim A.Y., Bommelje C.C., Lee B.E., Yonekawa Y., Choi L., Morris L.G., Huang G., Kaufman A., Ryan R.J., Hao B., Ramanathan Y., Singh B. J. Biol. Chem. 283:33211-33220(2008). [3]Two-step differential expression analysis reveals a new set of genes involved in thyroid oncocytic tumors. Jacques C., Baris O., Prunier-Mirebeau D., Savagner F., Rodien P., Rohmer V., Franc B., Guyetant S., Malthiery Y., Reynier P. J. Clin. Endocrinol. Metab. 90:2314-2320(2005).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	DCN1,defective in cullin neddylation 1,domain containing 1;DCN1-like protein 1;DCNL1;DCUN1 domain-containing protein 1;DCUN1L1;defective in cullin neddylation protein 1-like protein 1;RP42;RP42 homolog;SCCRO;SCRO;squamous cell carcinoma-related oncogene;Tes3.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	DCUN1D1
Gene Fullname	defective in cullin neddylation 1 domain containing 1
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity (PubMed:25349211, PubMed:28581483). Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity).
Nucleotide accession_num	NM_001308101
Protein accession_num	NP_001295030
Protein name	DCN1-like protein 1
Clonality	Polyclonal
Purification	Protein G Purified
Immunogen	Recombinant Human DCN1-like protein 1 protein (1-259AA)
Formulation	50% Glycerol, 0.01M PBS, PH 7.4

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