CEP63 Antibody

ArtNr	OACA05550
Hersteller	AVIVA Systems Biology
Menge	50 ug
Kategorie	Oncology Antibodies By Cell Type Carcinoma Hematology Lymphoma Immunohistochemistry Western Blot ELISA Primary Antibodies By Organ Lung Cancer Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IHC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB." Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R. Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2011). [2]"A primary microcephaly protein complex forms a ring around parental centrioles." Sir J.H., Barr A.R., Nicholas A.K., Carvalho O.P., Khurshid M., Sossick A., Reichelt S., D'Santos C., Woods C.G., Gergely F. Nat. Genet. 43:1147-1153(2010). [3]"Cep63 recruits Cdk1 to the centrosome: implications for regulation of mitotic entry, centrosome amplification, and genome maintenance." Loffler H., Fechter A., Matuszewska M., Saffrich R., Mistrik M., Marhold J., Hornung C., Westermann F., Bartek J., Kramer A. Cancer Res. 71:2129-2139(2010).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	centrosomal protein 63kDa;centrosomal protein of 63 kDa;centrosome protein CEP63;SCKL6.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	CEP63
Gene Fullname	centrosomal protein 63
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned (PubMed:21983783, PubMed:26297806). Also recruits CDK1 to centrosomes (PubMed:21406398). Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (PubMed:21406398).
Nucleotide accession_num	NM_001042383
Protein accession_num	NP_001035842
Protein name	Centrosomal protein of 63 kDa
Clonality	Polyclonal
Purification	Protein G Purified
Immunogen	Recombinant Human Centrosomal protein of 63 kDa protein (1-495AA)
Formulation	50% Glycerol, 0.01M PBS, PH 7.4

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