ITGB3 Antibody

ArtNr	OACA06609
Hersteller	AVIVA Systems Biology
Menge	50 ul
Kategorie	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Metabolism Glucose Homeostasis Cholesterol & Lipid Metabolism Molecular Targets for Neuroscience Neural Signaling Neural Adhesion Molecules Antibodies By Cell Type Carcinoma Glioma Hematology Leukemia Myeloma Melanoma Sarcoma Cell Biology Cell Movement Cell Adhesion Cell Culture Cytokines Adenocarcinoma Flow Cytometry Immunohistochemistry Western Blot ELISA Endocrine Regulation of Lipid Metabolism Enzymes Fatty Acid Catabolism Primary Antibodies By Organ Bladder Cancer Immunostaining Neuronal Cell Markers
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]AlphaIIbbeta3 integrin: new allelic variants in Glanzmann thrombasthenia, effects on ITGA2B and ITGB3 mRNA splicing, expression, and structure-function." Jallu V., Dusseaux M., Panzer S., Torchet M.F., Hezard N., Goudemand J., de Brevern A.G., Kaplan C. Hum. Mutat. 31:237-246(2010). [2]A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the alphaIIbbeta3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia." Ghevaert C., Salsmann A., Watkins N.A., Schaffner-Reckinger E., Rankin A., Garner S.F., Stephens J., Smith G.A., Debili N., Vainchenker W., de Groot P.G., Huntington J.A., Laffan M., Kieffer N., Ouwehand W.H. Blood 111:3407-3414(2008). [3]Mutations in GPIIIa molecule as a cause for Glanzmann thrombasthenia in Indian patients." Nair S., Ghosh K., Shetty S., Mohanty D.J. Thromb. Haemost. 3:482-488(2005).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	antigen CD61;BDPLT16;BDPLT2;BDPLT24;CD61;GP3A;GPIIIa;GT;GT2;integrin beta 3;integrin beta chain,beta 3;integrin beta-3;integrin,beta 3 (platelet glycoprotein IIIa,antigen CD61);platelet membrane glycoprotein IIIa.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	ITGB3
Gene Fullname	integrin subunit beta 3
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and acts as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887).
Nucleotide accession_num	NM_000212
Protein accession_num	NP_000203
Protein name	Integrin beta-3
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Integrin beta-3 protein (609-788AA)
Formulation	PBS with, 50% glycerol, pH7.3.

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