NCK1 Antibody

ArtNr	OACA06623
Hersteller	AVIVA Systems Biology
Menge	50 ul
Kategorie	Oncology Neuroscience Neural Lineage Markers Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Cell Biology Cell Movement Cell Adhesion Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IHC, ELISA
Specific against	Human (Homo sapiens), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]Specificity determinants of a novel Nck interaction with the juxtamembrane domain of the epidermal growth factor receptor."Hake M.J., Choowongkomon K., Kostenko O., Carlin C.R., Sonnichsen F.D.Biochemistry 47:3096-3108(2008). [2]Solution structure of the SH3 domain of the human cytoplasmic protein NCK1."RIKEN structural genomics initiative (RSGI)Submitted (NOV-2005). [3]Receptor protein tyrosine phosphatase-receptor tyrosine kinase substrate screen identifies EphA2 as a target for LAR in cell migration."Lee H., Bennett A.M.Mol. Cell. Biol. 33:1430-1441(2013).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	cytoplasmic protein NCK1;melanoma NCK protein;NCK;NCK adaptor protein 1;NCK tyrosine kinase;nck-1;NCKalpha;non-catalytic region of tyrosine kinase;SH2/SH3 adaptor protein NCK-alpha.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	NCK1
Gene Fullname	NCK adaptor protein 1
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors.
Nucleotide accession_num	NM_001190796
Protein accession_num	NP_001177725
Protein name	Cytoplasmic protein NCK1
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Cytoplasmic protein NCK1 protein (58-377AA)
Formulation	PBS with, 50% glycerol, pH7.3.

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