IFNAR2 Antibody

ArtNr	OACA06640
Hersteller	AVIVA Systems Biology
Menge	50 ul
Kategorie	Oncology Neuroscience Neural Lineage Markers Neural Transcription Factors Targets for Rodent Neurosciences Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Adenocarcinoma Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]Structural linkage between ligand discrimination and receptor activation by type I interferons." Thomas C., Moraga I., Levin D., Krutzik P.O., Podoplelova Y., Trejo A., Lee C., Yarden G., Vleck S.E., Glenn J.S., Nolan G.P., Piehler J., Schreiber G., Garcia K.C.Cell 146:621-632(2011). [2]Intermolecular interactions in a 44 kDa interferon-receptor complex detected by asymmetric reverse-protonation and two-dimensional NOESY."Nudelman I., Akabayov S.R., Schnur E., Biron Z., Levy R., Xu Y., Yang D., Anglister J.Biochemistry 49:5117-5133(2010). [3]Determination of the human type I interferon receptor binding site on human interferon-alpha2 by cross saturation and an NMR-based model of the complex." Quadt-Akabayov S.R., Chill J.H., Levy R., Kessler N., Anglister J.Protein Sci. 15:2656-2668(2006).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	human interferon alpha/beta receptor;IFNABR;IFN-alpha/beta receptor 2;IFNalpha/beta receptor subunit 2;IFN-alpha-REC;IFNARB;IFN-R;IFN-R-2;IMD45;interferon (alpha,beta and omega) receptor 2;interferon alpha binding protein;interferon alpha/beta receptor 2;interferon receptor;interferon-alpha/beta receptor beta chain;type I interferon receptor 2.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	IFNAR2
Gene Fullname	interferon alpha and beta receptor subunit 2
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569). Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed:7759950).
Nucleotide accession_num	NM_000874
Protein accession_num	NP_000865
Protein name	Interferon alpha/beta receptor 2
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Interferon alpha/beta receptor 2 protein (27-243AA)
Formulation	PBS with, 50% glycerol, pH7.3.

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