EFNB2 Antibody

ArtNr	OACA06706
Hersteller	AVIVA Systems Biology
Menge	50 ul
Kategorie	Oncology Neuroscience Molecular Targets for Neuroscience Antibodies By Cell Type Carcinoma Hematology Leukemia Myeloma Melanoma Sarcoma Myelofibrosis Mesothelioma Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]Structural characterization of the EphA4-Ephrin-B2 complex reveals new features enabling Eph-ephrin binding promiscuity."Qin H., Noberini R., Huan X., Shi J., Pasquale E.B., Song J.J. Biol. Chem. 285:644-654(2010). [2]Structural plasticity of EPH receptor A4 facilitates cross-class ephrin signaling."Bowden T.A., Aricescu A.R., Nettleship J.E., Siebold C., Rahman-Huq N., Owens R.J., Stuart D.I., Jones E.Y.Structure 17:1386-1397(2009). [3]Structural basis of Nipah and Hendra virus attachment to their cell-surface receptor ephrin-B2."Bowden T.A., Aricescu A.R., Gilbert R.J., Grimes J.M., Jones E.Y., Stuart D.I.Nat. Struct. Mol. Biol. 15:567-572(2008).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	eph-related receptor tyrosine kinase ligand 5;ephrin-B2;EPLG5;HTK ligand;Htk-L;HTKL;LERK5;ligand of eph-related kinase 5.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	EFNB2
Gene Fullname	ephrin B2
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.
Nucleotide accession_num	NM_004093
Protein accession_num	NP_004084
Protein name	Ephrin-B2
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Ephrin-B2 protein (28-229AA)
Formulation	PBS with, 50% glycerol, pH7.3.

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