FGF1 Antibody

ArtNr	OACA06749
Hersteller	AVIVA Systems Biology
Menge	50 ul
Kategorie	Oncology Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders Neural Signaling Neural Adhesion Molecules Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Cell Biology Cell Culture Cytokines Adenocarcinoma Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies By Organ Bladder Cancer Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	IF, IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]The heterohexameric complex structure, a component in the non-classical pathway for fibroblast growth factor 1 (FGF1) secretion."Mohan S.K., Rani S.G., Yu C.J. Biol. Chem. 285:15464-15475(2010). [2]Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors." Fernandez I.S., Cuevas P., Angulo J., Lopez-Navajas P., Canales-Mayordomo A., Gonzalez-Corrochano R., Lozano R.M., Valverde S., Jimenez-Barbero J., Romero A., Gimenez-Gallego G.J. Biol. Chem. 285:11714-11729(2010). [3]Solution structure of acidic fibroblast growth factor bound to 1,3, 6-naphthalenetrisulfonate: a minimal model for the anti-tumoral action of suramins and suradistas." Lozano R.M., Jimenez M., Santoro J., Rico M., Gimenez-Gallego G.J. Mol. Biol. 281:899-915(1998).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Acidic fibroblast growth factor;AFGF;beta-endothelial cell growth factor;ECGF;ECGFA;ECGFB;ECGF-beta;Endothelial cell growth factor;endothelial cell growth factor,alpha;endothelial cell growth factor,beta;FGF-1;FGFA;FGF-alpha;fibroblast growth factor 1;fibroblast growth factor 1 (acidic);GLIO703;HBGF1;HBGF-1;heparin-binding growth factor 1.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	FGF1
Gene Fullname	fibroblast growth factor 1
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107).
Nucleotide accession_num	NM_000800
Protein accession_num	NP_000791
Protein name	Fibroblast growth factor 1
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Fibroblast growth factor 1 protein (16-155AA)
Formulation	PBS with, 50% glycerol, pH7.3.

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