CADM1 Antibody

ArtNr	OACA06822
Hersteller	AVIVA Systems Biology
Menge	50 ul
Kategorie	Oncology Neuroscience Targets for Rodent Neurosciences Antibodies By Cell Type Melanoma Immunohistochemistry ELISA Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]Structural basis of tumor suppressor in lung cancer 1 (TSLC1) binding to differentially expressed in adenocarcinoma of the lung (DAL-1/4.1B)." Busam R.D., Thorsell A.G., Flores A., Hammarstrom M., Persson C., Obrink B., Hallberg B.M.J. Biol. Chem. 286:4511-4516(2011). [2]Initial characterization of the human central proteome."Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011). [3]Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol. 27:378-386(2009).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	BL2;cell adhesion molecule 1;IGSF4;IGSF4A;immunoglobulin superfamily member 4;immunoglobulin superfamily,member 4D variant 1;immunoglobulin superfamily,member 4D variant 2;Necl-2;NECL2;nectin-like 2;nectin-like protein 2;RA175;sgIGSF;spermatogenic immunoglobulin superfamily;ST17;sTSLC-1;synaptic cell adhesion molecule;SYNCAM;synCAM1;truncated CADM1 protein;TSLC1;TSLC-1;TSLC1/Nectin-like 2/IGSF4;tumor suppressor in lung cancer 1.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Manufacturer - Application Additional Information	IHC: 1:20~200
Gene symbol	CADM1
Gene Fullname	cell adhesion molecule 1
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
Nucleotide accession_num	NM_001098517
Protein accession_num	NP_001091987
Protein name	Cell adhesion molecule 1
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Cell adhesion molecule 1 protein (45-344AA)
Formulation	PBS with, 50% glycerol, pH7.3.
Concentration	Varies by lot. See vial for concentration.

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