CD22 Antibody

ArtNr	OACA06851
Hersteller	AVIVA Systems Biology
Menge	50 ul
Kategorie	Oncology Neuroscience Aging & Neurological Disorders Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Adenocarcinoma Flow Cytometry Immunohistochemistry Immunoprecipitation Western Blot ELISA Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]"CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling." Tedder T.F., Tuscano J., Sato S., Kehrl J.H.Annu. Rev. Immunol. 15:481-504(1997). [2]"CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation." Law C.L., Sidorenko S.P., Chandran K.A., Zhao Z., Shen S.H., Fischer E.H., Clark E.A. J. Exp. Med. 183:547-560(1996). [3]"Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22."Tuscano J.M., Engel P., Tedder T.F., Agarwal A., Kehrl J.H.Eur. J. Immunol. 26:1246-1252(1996).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	B-cell receptor CD22;BL-CAM;B-lymphocyte cell adhesion molecule;CD22 antigen;sialic acid-binding Ig-like lectin 2;SIGLEC2;SIGLEC-2;T-cell surface antigen Leu-14.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	CD22
Gene Fullname	CD22 molecule
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2, 6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Nucleotide accession_num	NM_001185099
Protein accession_num	NP_001172028
Protein name	B-cell receptor CD22
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human B-cell receptor CD22 protein (708-847AA)
Formulation	PBS with, 50% glycerol, pH7.3.

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