LDLRAP1 Antibody

ArtNr	OACA06934
Hersteller	AVIVA Systems Biology
Menge	50 ul
Kategorie	Neuroscience Neuroinflammation Metabolism Glucose Homeostasis Cholesterol & Lipid Metabolism Targets for Rodent Neurosciences Aging & Neurological Disorders Antibodies Obesity Immunohistochemistry Western Blot ELISA Immunofluorescence Lipoprotein Receptors & Associated Proteins Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]"Molecular mechanisms of autosomal recessive hypercholesterolemia."Wilund K.R., Yi M., Campagna F., Arca M., Zuliani G., Fellin R., Ho Y.K., Garcia J.V., Hobbs H.H., Cohen J.C.Hum. Mol. Genet. 11:3019-3030(2002). [2]"The full-ORF clone resource of the German cDNA consortium."Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.BMC Genomics 8:399-399(2007). [3]"ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2." He G., Gupta S., Yi M., Michaely P., Hobbs H.H., Cohen J.C.J. Biol. Chem. 277:44044-44049(2002).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	ARH;ARH1;ARH2;autosomal recessive hypercholesterolemia protein;FHCB1;FHCB2;FHCL4;LDL receptor adaptor protein;low density lipoprotein receptor adapter protein 1.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	LDLRAP1
Gene Fullname	low density lipoprotein receptor adaptor protein 1
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression (By similarity).
Nucleotide accession_num	NM_015627
Protein accession_num	NP_056442
Protein name	Low density lipoprotein receptor adapter protein 1
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Low density lipoprotein receptor adapter protein 1 protein (59-308AA)
Formulation	PBS with, 50% glycerol, pH7.3.

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