MTM1 Antibody

ArtNr	OACA06952
Hersteller	AVIVA Systems Biology
Menge	50 ul
Kategorie	Oncology Neuroscience Neural Signaling Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Lymphoma Myeloma Melanoma Sarcoma Adenocarcinoma Immunohistochemistry Western Blot ELISA Primary Antibodies Astrocytoma By Organ Bladder Cancer Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]"X-linked myotubular myopathy with a novel MTM1 mutation in a Taiwanese child." Chang C.Y., Lin S.P., Lin H.Y., Chuang C.K., Ho C.S., Su Y.N.J. Formos. Med. Assoc. 107:965-970(2008). [2]"Extreme phenotypic variability in a German family with X-linked myotubular myopathy associated with E404K mutation in MTM1."Hoffjan S., Thiels C., Vorgerd M., Neuen-Jacob E., Epplen J.T., Kress W.Neuromuscul. Disord. 16:749-753(2006). [3]"Characterisation of mutations in 77 patients with X-linked myotubular myopathy, including a family with a very mild phenotype."Biancalana V., Caron O., Gallati S., Baas F., Kress W., Novelli G., D'Apice M.R., Lagier-Tourenne C., Buj-Bello A., Romero N.B., Mandel J.-L.Hum. Genet. 112:135-142(2003).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	CNM;MTMX;myotubularin;phosphatidylinositol-3,5-bisphosphate 3-phosphatase;phosphatidylinositol-3-phosphate phosphatase;XLMTM.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	MTM1
Gene Fullname	myotubularin 1
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3, 5-bisphosphate (PI(3, 5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis.
Nucleotide accession_num	NM_000252
Protein accession_num	NP_000243
Protein name	Myotubularin
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Myotubularin protein (484-603AA)
Formulation	PBS with, 50% glycerol, pH7.3.

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