JMJD6 Antibody

ArtNr	OACA06983
Hersteller	AVIVA Systems Biology
Menge	50 ul
Kategorie	Antibodies Cell Biology Cell Status Apoptosis Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]"Interaction of JMJD6 with single-stranded RNA."Hong X., Zang J., White J., Wang C., Pan C.H., Zhao R., Murphy R.C., Dai S., Henson P., Kappler J.W., Hagman J., Zhang G. Proc. Natl. Acad. Sci. U.S.A. 107:14568-14572(2010). [2]"Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6."Mantri M., Krojer T., Bagg E.A., Webby C.J., Butler D.S., Kochan G., Kavanagh K.L., Oppermann U., McDonough M.A., Schofield C.J.J. Mol. Biol. 401:211-222(2010). [3]"The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3."Rahman S., Sowa M.E., Ottinger M., Smith J.A., Shi Y., Harper J.W., Howley P.M.Mol. Cell. Biol. 31:2641-2652(2011).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	arginine demethylase and lysine hydroxylase;bifunctional arginine demethylase and lysyl-hydroxylase JMJD6;histone arginine demethylase JMJD6;jmjC domain-containing protein 6;jumonji domain-containing protein 6;lysyl-hydroxylase JMJD6;peptide-lysine 5-dioxygenase JMJD6;phosphatidylserine receptor;PSR;PTDSR;PTDSR1.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	JMJD6
Gene Fullname	jumonji domain containing 6, arginine demethylase and lysine hydroxylase
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses.
Nucleotide accession_num	NM_001081461
Protein accession_num	NP_001074930
Protein name	Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 protein (1-320AA)
Formulation	PBS with, 50% glycerol, pH7.3.

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