MAGEA1 Antibody

ArtNr	OACA07008
Hersteller	AVIVA Systems Biology
Menge	50 ul
Kategorie	Oncology Neuroscience Aging & Neurological Disorders Neural Epigenetics Antibodies By Cell Type Carcinoma Hematology Lymphoma Melanoma Sarcoma Immunohistochemistry Immunoprecipitation Western Blot ELISA Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	IP, IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]"The consensus coding sequences of human breast and colorectal cancers."Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. Velculescu V.E.Science 314:268-274(2006). [2]"Conformational changes within the HLA-A1:MAGE-A1 complex induced by binding of a recombinant antibody fragment with TCR-like specificity." Kumar P., Vahedi-Faridi A., Saenger W., Ziegler A., Uchanska-Ziegler B. Protein Sci. 18:37-49(2009). [3]"A major histocompatibility complex-peptide-restricted antibody and t cell receptor molecules recognize their target by distinct binding modes: crystal structure of human leukocyte antigen (HLA)-A1-MAGE-A1 in complex with FAB-HYB3."Hulsmeyer M., Chames P., Hillig R.C., Stanfield R.L., Held G., Coulie P.G., Alings C., Wille G., Saenger W., Uchanska-Ziegler B., Hoogenboom H.R., Ziegler A.J. Biol. Chem. 280:2972-2980(2005).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	antigen MZ2-E;cancer/testis antigen 1.1;cancer/testis antigen family 1,member 1;CT1.1;MAGE1;MAGE-1 antigen;melanoma antigen family A 1;melanoma antigen family A,1 (directs expression of antigen MZ2-E);melanoma antigen family A1;melanoma antigen MAGE-1;melanoma-associated antigen 1;melanoma-associated antigen MZ2-E.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	MAGEA1
Gene Fullname	MAGE family member A1
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
Nucleotide accession_num	NM_004988
Protein accession_num	NP_004979
Protein name	Melanoma-associated antigen 1
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Melanoma-associated antigen 1 protein (1-309AA)
Formulation	PBS with, 50% glycerol, pH7.3.

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