IL1R1 Antibody

ArtNr	OACA07017
Hersteller	AVIVA Systems Biology
Menge	50 ul
Kategorie	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Metabolism Cholesterol & Lipid Metabolism Molecular Targets for Neuroscience Neural Signaling Antibodies By Cell Type Blastoma Carcinoma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Cell Biology Cell Movement Cell Adhesion Cell Culture Cytokines Adenocarcinoma Immunohistochemistry Western Blot ELISA Primary Antibodies Astrocytoma By Organ Immunostaining Lymphatic System Cancer Neuronal Cell Markers
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IHC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]"X-ray crystal structure of a small antagonist peptide bound to interleukin-1 receptor type 1."Vigers G.P.A., Dripps D.J., Edwards C.K. III, Brandhuber B.J.J. Biol. Chem. 275:36927-36933(2000). [2]"A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist."Schreuder H., Tardif C., Trump-Kallmeyer S., Soffientini A., Sarubbi E., Akeson A., Bowlin T., Yanofsky S., Barrett R.W.Nature 386:194-200(1997). [3]"Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta." Vigers G.P.A., Anderson L.J., Caffes P., Brandhuber B.J.Nature 386:190-194(1997).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	CD121 antigen-like family member A;CD121A;D2S1473;IL1R;IL-1R-1;IL1RA;IL-1R-alpha;IL-1RT1;IL-1RT-1;interleukin 1 receptor alpha,type I;interleukin-1 receptor alpha;interleukin-1 receptor type 1;interleukin-1 receptor type I;P80.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	IL1R1
Gene Fullname	interleukin 1 receptor type 1
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850).
Nucleotide accession_num	NM_000877
Protein accession_num	NP_000868
Protein name	Interleukin-1 receptor type 1
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Interleukin-1 receptor type 1 protein (18-320AA)
Formulation	PBS with, 50% glycerol, pH7.3.

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