TARDBP Antibody

ArtNr	OACA07038
Hersteller	AVIVA Systems Biology
Menge	50 ul
Kategorie	Oncology Neuroscience Metabolism Diabetes Molecular Targets for Neuroscience Targets for Rodent Neurosciences Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Neural Development Antibodies By Cell Type Blastoma Immunohistochemistry Immunoprecipitation Western Blot ELISA Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IP, IHC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]"Novel TARDBP mutations in Nordic ALS patients."Chiang H.H., Andersen P.M., Tysnes O.B., Gredal O., Christensen P.B., Graff C.J. Hum. Genet. 57:316-319(2012). [2]"High frequency of the TARDBP p.Ala382Thr mutation in Sardinian patients with amyotrophic lateral sclerosis."Orru S., Manolakos E., Orru N., Kokotas H., Mascia V., Carcassi C., Petersen M.B.Clin. Genet. 81:172-178(2012). [3]"Large proportion of amyotrophic lateral sclerosis cases in Sardinia due to a single founder mutation of the TARDBP gene."Chio A., Borghero G., Pugliatti M., Ticca A., Calvo A., Moglia C., Mutani R., Brunetti M., Ossola I., Marrosu M.G., Murru M.R., Floris G., Cannas A., Parish L.D., Cossu P., Abramzon Y., Johnson J.O., Nalls M.A. Restagno G.Arch. Neurol. 68:594-598(2011).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	ALS10;TAR DNA-binding protein 43;TAR DNA-binding protein-43;TDP-43.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	TARDBP
Gene Fullname	TAR DNA binding protein
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.
Nucleotide accession_num	NM_007375
Protein accession_num	NP_031401
Protein name	TAR DNA-binding protein 43
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human TAR DNA-binding protein 43 protein (1-260AA)
Formulation	PBS with, 50% glycerol, pH7.3.

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