HTR2B Antibody

ArtNr	OACA07043
Hersteller	AVIVA Systems Biology
Menge	50 ul
Kategorie	Neuroscience Neural Signaling Antibodies Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]"Structural features for functional selectivity at serotonin receptors." Wacker D., Wang C., Katritch V., Han G.W., Huang X.P., Vardy E., McCorvy J.D., Jiang Y., Chu M., Siu F.Y., Liu W., Xu H.E., Cherezov V., Roth B.L., Stevens R.C. Science 340:615-619(2013). [2]"Structural basis for molecular recognition at serotonin receptors." Wang C., Jiang Y., Ma J., Wu H., Wacker D., Katritch V., Han G.W., Liu W., Huang X.P., Vardy E., McCorvy J.D., Gao X., Zhou X.E., Melcher K., Zhang C., Bai F., Yang H., Yang L. Xu H.E. Science 340:610-614(2013). [3]"Serotonin receptors - from molecular biology to clinical applications." Pytliak M., Vargova V., Mechirova V., Felsoci M.Physiol. Res. 60:15-25(2011).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	5-HT 2B receptor;5-HT(2B);5-HT2B;5-HT-2B;5-hydroxytryptamine (serotonin) receptor 2B,G protein-coupled;5-hydroxytryptamine 2B receptor;5-hydroxytryptamine receptor 2B;5-hydroxytryptamine receptor 2B variant b;serotonin receptor 2B.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	HTR2B
Gene Fullname	5-hydroxytryptamine receptor 2B
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:8143856, PubMed:7926008, PubMed:8078486, PubMed:8882600, PubMed:18703043, PubMed:23519210). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances (PubMed:8143856, PubMed:7926008, PubMed:8078486, PubMed:12970106, PubMed:18703043, PubMed:23519210, PubMed:23519215, PubMed:24357322, PubMed:28129538). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:8143856, PubMed:8078486, PubMed:8882600, PubMed:23519215, PubMed:28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:23519215, PubMed:28129538). Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores (PubMed:8143856, PubMed:8078486, PubMed:8882600, PubMed:18703043, PubMed:23519215, PubMed:28129538). Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain (By similarity). Plays a role in the regulation of behavior, including impulsive behavior (PubMed:21179162). Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine (By similarity).
Nucleotide accession_num	NM_000867
Protein accession_num	NP_000858
Protein name	5-hydroxytryptamine receptor 2B
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human 5-hydroxytryptamine receptor 2B protein (382-481AA)
Formulation	PBS with, 50% glycerol, pH7.3.

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