EFNA1 Antibody

ArtNr	OACA07051
Hersteller	AVIVA Systems Biology
Menge	50 ul
Kategorie	Oncology Neuroscience Metabolism Cholesterol & Lipid Metabolism Neural Signaling Neural Adhesion Molecules Antibodies By Cell Type Carcinoma Hematology Lymphoma Myeloma Sarcoma Cell Biology Cytoskeleton Immunohistochemistry ELISA Primary Antibodies Immunostaining small GTPases Rho Subfamily
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]"Architecture of Eph receptor clusters."Himanen J.P., Yermekbayeva L., Janes P.W., Walker J.R., Xu K., Atapattu L., Rajashankar K.R., Mensinga A., Lackmann M., Nikolov D.B., Dhe-Paganon S.Proc. Natl. Acad. Sci. U.S.A. 107:10860-10865(2010). [2]"Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex."Himanen J.P., Goldgur Y., Miao H., Myshkin E., Guo H., Buck M., Nguyen M., Rajashankar K.R., Wang B., Nikolov D.B. EMBO Rep. 10:722-728(2009). [3]"Biological and structural characterization of glycosylation on ephrin-A1, a preferred ligand for EphA2 receptor tyrosine kinase."Ferluga S., Hantgan R., Goldgur Y., Himanen J.P., Nikolov D.B., Debinski W.J. Biol. Chem. 288:18448-18457(2013).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	B61;ECKLG;EFL1;eph-related receptor tyrosine kinase ligand 1;ephrin-A1;epididymis secretory sperm binding protein;EPLG1;gastric cancer metastasis associated long noncoding RNA;GMAN;immediate early response protein B61;LERK1;LERK-1;ligand of eph-related kinase 1;TNF alpha-induced protein 4;TNFAIP4;Tumor necrosis factor alpha-induced protein 4;tumor necrosis factor,alpha-induced protein 4.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	EFNA1
Gene Fullname	ephrin A1
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.
Nucleotide accession_num	NM_004428
Protein accession_num	NP_004419
Protein name	Ephrin-A1
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Ephrin-A1 protein (19-182AA)
Formulation	PBS with, 50% glycerol, pH7.3.

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