SIRT3 Antibody

ArtNr	OACA07063
Hersteller	AVIVA Systems Biology
Menge	50 ul
Kategorie	Oncology Neuroscience Targets for Rodent Neurosciences Aging & Neurological Disorders Antibodies By Cell Type Carcinoma Glioma Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]"Structures of human sirtuin 3 complexes with ADP-ribose and with carba-NAD+ and SRT1720: binding details and inhibition mechanism."Nguyen G.T., Schaefer S., Gertz M., Weyand M., Steegborn C.Acta Crystallogr. D 69:1423-1432(2013). [2]"Crystal structures of human SIRT3 displaying substrate-induced conformational changes."Jin L., Wei W., Jiang Y., Peng H., Cai J., Mao C., Dai H., Choy W., Bemis J.E., Jirousek M.R., Milne J.C., Westphal C.H., Perni R.B.J. Biol. Chem. 284:24394-24405(2009). [3]"SIRT3 regulates long-chain acyl-coA dehydrogenase by deacetylating conserved lysines near the active site."Bharathi S.S., Zhang Y., Mohsen A.W., Uppala R., Balasubramani M., Schreiber E., Uechi G., Beck M.E., Rardin M.J., Vockley J., Verdin E., Gibson B.W., Hirschey M.D., Goetzman E.S.J. Biol. Chem. 288:33837-33847(2013).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase;NAD-dependent deacetylase sirtuin-3,mitochondrial;NAD-dependent protein deacetylase sirtuin-3,mitochondrial;regulatory protein SIR2 homolog 3;silent mating type information regulation 2,S.cerevisiae,homolog 3;SIR2L3;sir2-like 3;SIR2-like protein 3;sirtuin type 3.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	SIRT3
Gene Fullname	sirtuin 3
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	NAD-dependent protein deacetylase (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090, PubMed:19535340). Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090). Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5O (PubMed:16788062, PubMed:18680753, PubMed:24121500, PubMed:24252090, PubMed:19535340). Contributes to the regulation of the cellular energy metabolism (PubMed:24252090). Important for regulating tissue-specific ATP levels (PubMed:18794531). In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed:23283301).
Nucleotide accession_num	NM_001017524
Protein accession_num	NP_001017524
Protein name	NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human NAD-dependent protein deacetylase sirtuin-3, mitochondrial protein (20-130AA)
Formulation	PBS with, 50% glycerol, pH7.3.

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