PDCD4 Antibody

ArtNr	OACA07074
Hersteller	AVIVA Systems Biology
Menge	50 ul
Kategorie	Oncology Neuroscience Targets for Rodent Neurosciences Antibodies By Cell Type Carcinoma Cell Biology Cell Status Apoptosis Immunoprecipitation Western Blot ELISA Primary Antibodies By Organ Bladder Cancer Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IP, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. Velculescu V.E.Science 314:268-274(2006). [2]"Structural basis for translational inhibition by the tumour suppressor Pdcd4." Loh P.G., Yang H.S., Walsh M.A., Wang Q., Wang X., Cheng Z., Liu D., Song H. EMBO J. 28:274-285(2009). [3]"PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains." Suzuki C., Garces R.G., Edmonds K.A., Hiller S., Hyberts S.G., Marintchev A., Wagner G. Proc. Natl. Acad. Sci. U.S.A. 105:3274-3279(2008).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	H731;neoplastic transformation inhibitor protein;nuclear antigen H731;Nuclear antigen H731-like;programmed cell death 4 (neoplastic transformation inhibitor);programmed cell death protein 4;protein 197/15a.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	PDCD4
Gene Fullname	programmed cell death 4
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).
Nucleotide accession_num	NM_014456
Protein accession_num	NP_055271
Protein name	Programmed cell death protein 4
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Programmed cell death protein 4 protein (1-260AA)
Formulation	PBS with, 50% glycerol, pH7.3.

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