RRM2B Antibody

ArtNr	OACA07222
Hersteller	AVIVA Systems Biology
Menge	50 ul
Kategorie	Oncology Neuroscience Targets for Rodent Neurosciences Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Adenocarcinoma Immunohistochemistry Western Blot ELISA Primary Antibodies Astrocytoma By Organ Breast Cancer Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]"Mitochondrial neurogastrointestinal encephalopathy due to mutations in RRM2B." Shaibani A., Shchelochkov O.A., Zhang S., Katsonis P., Lichtarge O., Wong L.J., Shinawi M. Arch. Neurol. 66:1028-1032(2009). [2]"Mitochondrial DNA depletion syndrome due to mutations in the RRM2B gene." Bornstein B., Area E., Flanigan K.M., Ganesh J., Jayakar P., Swoboda K.J., Coku J., Naini A., Shanske S., Tanji K., Hirano M., DiMauro S.Neuromuscul. Disord. 18:453-459(2008). [3]"Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion."Bourdon A., Minai L., Serre V., Jais J.-P., Sarzi E., Aubert S., Chretien D., de Lonlay P., Paquis-Flucklinger V., Arakawa H., Nakamura Y., Munnich A., Roetig A.Nat. Genet. 39:776-780(2007).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	MTDPS8A;MTDPS8B;p53-inducible ribonucleotide reductase small subunit 2 homolog;p53-inducible ribonucleotide reductase small subunit 2 short form beta;p53-inducible ribonucleotide reductase small subunit 2-like protein;P53R2;ribonucleoside-diphosphate reductase subunit M2 B;ribonucleotide reductase M2 B (TP53 inducible);TP53-inducible ribonucleotide reductase M2 B.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	RRM2B
Gene Fullname	ribonucleotide reductase regulatory TP53 inducible subunit M2B
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.
Nucleotide accession_num	NM_001172477
Protein accession_num	NP_001165948
Protein name	Ribonucleoside-diphosphate reductase subunit M2 B
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Ribonucleoside-diphosphate reductase subunit M2 B protein (1-351AA)
Formulation	PBS with, 50% glycerol, pH7.3.

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