AUH Antibody

ArtNr	OACA07264
Hersteller	AVIVA Systems Biology
Menge	50 ul
Kategorie	Neuroscience Neuroinflammation Antibodies Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IHC, ELISA
Specific against	Human (Homo sapiens), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]"Mutations in the AUH gene cause 3-methylglutaconic aciduria type I." Ly T.B.N., Peters V., Gibson K.M., Liesert M., Buckel W., Wilcken B., Carpenter K., Ensenauer R., Hoffmann G.F., Mack M., Zschocke J.Hum. Mutat. 21:401-407(2003). [2]"Crystal structure of human AUH protein, a single-stranded RNA binding homolog of enoyl-CoA hydratase."Kurimoto K., Fukai S., Nureki O., Muto Y., Yokoyama S.Structure 9:1253-1263(2001). [3]"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.J. Proteomics 96:253-262(2014).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	3-methylglutaconyl-CoA hydratase;AU RNA binding protein/enoyl-CoA hydratase;AU RNA-binding protein/enoyl-Coenzyme A hydratase;AU-binding protein/Enoyl-CoA hydratase;AU-specific RNA-binding enoyl-CoA hydratase;itaconyl-CoA hydratase;methylglutaconyl-CoA hydratase,mitochondrial.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	AUH
Gene Fullname	AU RNA binding methylglutaconyl-CoA hydratase
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Catalyzes the conversion of 3-methylglutaconyl-CoA to 3-hydroxy-3-methylglutaryl-CoA (PubMed:11738050, PubMed:12434311, PubMed:12655555). Also has itaconyl-CoA hydratase activity by converting itaconyl-CoA into citramalyl-CoA in the C5-dicarboxylate catabolism pathway (PubMed:29056341). The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite (PubMed:29056341). Has very low enoyl-CoA hydratase activity (PubMed:7892223). Was originally identified as RNA-binding protein that binds in vitro to clustered 5'-AUUUA-3' motifs (PubMed:7892223).
Nucleotide accession_num	NM_001306190
Protein accession_num	NP_001293119
Protein name	Methylglutaconyl-CoA hydratase, mitochondrial
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Methylglutaconyl-CoA hydratase, mitochondrial protein (68-339AA)
Formulation	PBS with, 50% glycerol, pH7.3.

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