APBB1 Antibody

ArtNr	OACA07361
Hersteller	AVIVA Systems Biology
Menge	50 ul
Kategorie	Oncology Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders Neural Epigenetics Protein Aggregation, Clearance & Misfolding Antibodies By Cell Type Melanoma Cell Biology Cell Status Apoptosis Adenocarcinoma Immunohistochemistry ELISA Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]"Crystal structure of the human Fe65-PTB1 domain."Radzimanowski J., Ravaud S., Schlesinger S., Koch J., Beyreuther K., Sinning I., Wild K.J. Biol. Chem. 283:23113-23120(2007). [2]"Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2."Radzimanowski J., Simon B., Sattler M., Beyreuther K., Sinning I., Wild K.EMBO Rep. 9:1134-1140(2007). [3]"Structural basis for polyproline recognition by the FE65 WW domain." Meiyappan M., Birrane G., Ladias J.A.A.J. Mol. Biol. 372:970-980(2006).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	adaptor protein FE65a2;amyloid beta (A4) precursor protein-binding,family B,member 1 (Fe65);amyloid-beta A4 precursor protein-binding family B member 1;FE65;MGC:9072;Protein Fe65;RIR;stat-like protein.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	APBB1
Gene Fullname	amyloid beta precursor protein binding family B member 1
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).
Nucleotide accession_num	NM_001164
Protein accession_num	NP_001155
Protein name	Amyloid-beta A4 precursor protein-binding family B member 1
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Amyloid beta A4 precursor protein-binding family B member 1 protein (361-710AA)
Formulation	PBS with, 50% glycerol, pH7.3.

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