COPS7A Antibody

ArtNr	OACA07395
Hersteller	AVIVA Systems Biology
Menge	50 ul
Kategorie	Oncology Neuroscience Metabolism Cholesterol & Lipid Metabolism Targets for Rodent Neurosciences Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Adenocarcinoma Immunohistochemistry Western Blot ELISA Primary Antibodies Astrocytoma By Organ Bladder Cancer Breast Cancer Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IHC, ELISA
Specific against	Human (Homo sapiens), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.J. Proteomics 96:253-262(2014). [2]"Initial characterization of the human central proteome."Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011). [3]"Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry."Fang L., Wang X., Yamoah K., Chen P.L., Pan Z.Q., Huang L.J. Proteome Res. 7:4914-4925(2008).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	COP9 complex subunit 7a;COP9 constitutive photomorphogenic homolog subunit 7A;COP9 signalosome complex subunit 7a;CSN7;CSN7A;dermal papilla-derived protein 10;JAB1-containing signalosome subunit 7a;SGN7a.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	COPS7A
Gene Fullname	COP9 signalosome subunit 7A
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Nucleotide accession_num	NM_001164093
Protein accession_num	NP_001157565
Protein name	COP9 signalosome complex subunit 7a
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human COP9 signalosome complex subunit 7a protein (1-275AA)
Formulation	PBS with, 50% glycerol, pH7.3.

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