TERF2IP Antibody

ArtNr	OACA07453
Hersteller	AVIVA Systems Biology
Menge	50 ul
Kategorie	Neuroscience Aging & Neurological Disorders Antibodies Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]"Cloning and characterization of DRIP5, a new protein that specifically interacts with the D1 dopamine receptor."Lafuente M.J., Nasir J.Submitted (MAR-2000). [2]"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004). [3]"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. Pennacchio L.A.Nature 432:988-994(2004).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	dopamine receptor-interacting protein 5;DRIP5;RAP1;repressor/activator protein 1 homolog;telomeric repeat-binding factor 2-interacting protein 1;TERF2-interacting telomeric protein 1;TRF2-interacting telomeric RAP1 protein.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	TERF2IP
Gene Fullname	TERF2 interacting protein
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes.
Nucleotide accession_num	NM_018975
Protein accession_num	NP_061848
Protein name	Telomeric repeat-binding factor 2-interacting protein 1
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Telomeric repeat-binding factor 2-interacting protein 1 protein (1-280AA)
Formulation	PBS with, 50% glycerol, pH7.3.

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