NLRP2 Antibody

ArtNr	OACA07505
Hersteller	AVIVA Systems Biology
Menge	50 ul
Kategorie	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Metabolism Diabetes Cholesterol & Lipid Metabolism Aging & Neurological Disorders Neural Signaling Antibodies By Cell Type Hematology Lymphoma Myeloma Cell Biology Cell Movement Cell Adhesion Obesity Cell Culture Cytokines Cell Status Necrosis Apoptosis Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining Neurodegeneration Markers
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]"The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation."Martinon F., Hofmann K., Tschopp J.Curr. Biol. 11:R118-R120(2001). [2]"PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing."Wang L., Manji G.A., Grenier J.M., Al-Garawi A., Merriam S., Lora J.M., Geddes B.J., Briskin M., DiStefano P.S., Bertin J.J. Biol. Chem. 277:29874-29880(2002). [3]"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	CLR19.9;NACHT,leucine rich repeat and PYD containing 2;NACHT,LRR and PYD domains-containing protein 2;NALP2;NBS1;nucleotide-binding oligomerization domain,leucine rich repeat and pyrin domain containing 2;nucleotide-binding site protein 1;PAN1;PYPAF2;PYRIN domain and NACHT domain-containing protein 1;PYRIN-containing APAF1-like protein 2.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	NLRP2
Gene Fullname	NLR family pyrin domain containing 2
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.
Nucleotide accession_num	NM_001174081
Protein accession_num	NP_001167552
Protein name	NACHT, LRR and PYD domains-containing protein 2
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human NACHT, LRR and PYD domains-containing protein 2 protein (1-220AA)
Formulation	PBS with, 50% glycerol, pH7.3.

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