GRIN2B Antibody

ArtNr	OACA07595
Hersteller	AVIVA Systems Biology
Menge	50 ul
Kategorie	Neuroscience Metabolism Diabetes Molecular Targets for Neuroscience Neural Signaling Antibodies Immunohistochemistry ELISA Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]"Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors."Hess S.D., Daggett L.P., Crona J., Deal C., Lu C.-C., Urrutia A., Chavez-Noriega L., Ellis S.B., Johnson E.C., Velicelebi G.J. Pharmacol. Exp. Ther. 278:808-816(1996). [2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."The MGC Project TeamGenome Res. 14:2121-2127(2004). [3]"Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase."Wu Y., Dowbenko D., Spencer S., Laura R., Lee J., Gu Q., Lasky L.A.J. Biol. Chem. 275:21477-21485(2000).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	DEE27;EIEE27;GluN2B;GluN2B(alt_5'UTR);glutamate [NMDA] receptor subunit epsilon-2;glutamate receptor ionotropic,NMDA 2B;glutamate receptor subunit epsilon-2;glutamate receptor,ionotropic,N-methyl D-aspartate 2B;hNR3;MRD6;NMDAR2B;N-methyl D-aspartate receptor subtype 2B;N-methyl-D-aspartate receptor subunit 3;NR2B;NR3.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	GRIN2B
Gene Fullname	glutamate ionotropic receptor NMDA type subunit 2B
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28126851). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:8768735, PubMed:26875626). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity (By similarity).
Nucleotide accession_num	NM_000834
Protein accession_num	NP_000825
Protein name	Glutamate receptor ionotropic, NMDA 2B
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Glutamate receptor ionotropic, NMDA 2B protein (1185-1484AA)
Formulation	PBS with, 50% glycerol, pH7.3.

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