SMAD3 Antibody

ArtNr	OACA07685
Hersteller	AVIVA Systems Biology
Menge	50 ul
Kategorie	Oncology Neuroscience Neural Lineage Markers Metabolism Cholesterol & Lipid Metabolism Neural Transcription Factors Targets for Rodent Neurosciences Neural Signaling Antibodies By Cell Type Carcinoma Hematology Leukemia Lymphoma Myeloma Cell Biology Cell Status Apoptosis Adenocarcinoma Immunohistochemistry Immunoprecipitation Western Blot ELISA Immunofluorescence Primary Antibodies By Organ Bladder Cancer Colorectal Cancer Immunostaining Neuronal Cell Markers
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, IP, IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]"Genomic structure of the human Smad3 gene and its infrequent alterations in colorectal cancers."Arai T., Akiyama Y., Okabe S., Ando M., Endo M., Yuasa Y. Cancer Lett. 122:157-163(1998). [2]"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	hMAD-3;hSMAD3;HSPC193;HsT17436;JV15-2;LDS1C;LDS3;MAD homolog 3;mad homolog JV15-2;mad protein homolog;MAD,mothers against decapentaplegic homolog 3;mad3;MADH3;mothers against decapentaplegic homolog 3;mothers against DPP homolog 3;SMA- and MAD-related protein 3;SMAD family member 3;SMAD,mothers against DPP homolog 3.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	SMAD3
Gene Fullname	SMAD family member 3
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Nucleotide accession_num	NM_001145102
Protein accession_num	NP_001138574
Protein name	Mothers against decapentaplegic homolog 3
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Mothers against decapentaplegic homolog 3 protein (1-230AA)
Formulation	PBS with, 50% glycerol, pH7.3.

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