EYA3 Antibody

ArtNr	OACA08320
Hersteller	AVIVA Systems Biology
Menge	50 ul
Kategorie	Oncology Neuroscience Neural Epigenetics Antibodies By Cell Type Carcinoma Melanoma Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	eyes absent 3;eyes absent homolog 3.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	EYA3
Gene Fullname	EYA transcriptional coactivator and phosphatase 3
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442, PubMed:19351884). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye.
Nucleotide accession_num	NM_001282560
Protein accession_num	NP_001269489
Protein name	Eyes absent homolog 3
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Eyes absent homolog 3 protein (1-300AA)
Formulation	PBS with, 50% glycerol, pH7.3.

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Menge: 50 ul

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Lieferung vsl. bis 25.12.2025

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