PSTPIP1 Antibody

ArtNr	OACA08653
Hersteller	AVIVA Systems Biology
Menge	50 ul
Kategorie	Oncology Neuroscience Molecular Targets for Neuroscience Protein Aggregation, Clearance & Misfolding Antibodies By Cell Type Blastoma Carcinoma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Immunohistochemistry Western Blot ELISA Primary Antibodies By Organ Colorectal Cancer Heart & Blood Cancer Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IHC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	CD2 antigen-binding protein 1;CD2 cytoplasmic tail-binding protein;CD2-binding protein 1;CD2BP1;CD2BP1L;CD2BP1S;H-PIP;PAPAS;PEST phosphatase-interacting protein 1;proline-serine-threonine phosphatase-interacting protein 1;PSTPIP;truncated proline-serine-threonine phosphatase interacting protein 1.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	PSTPIP1
Gene Fullname	proline-serine-threonine phosphatase interacting protein 1
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils.
Nucleotide accession_num	NM_001321135
Protein accession_num	NP_001308064
Protein name	Proline-serine-threonine phosphatase-interacting protein 1
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Proline-serine-threonine phosphatase-interacting protein 1 protein (157-416AA)
Formulation	PBS with, 50% glycerol, pH7.3.

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Menge: 50 ul

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