FBXO6 Antibody

ArtNr	OACA08868
Hersteller	AVIVA Systems Biology
Menge	50 ul
Kategorie	Oncology Antibodies By Cell Type Blastoma Carcinoma Hematology Lymphoma Myeloma Melanoma Sarcoma Adenocarcinoma Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	FBG2;F-box only protein 6;F-box protein FBG2;F-box protein Fbx6;F-box protein that recognizes sugar chains 2;F-box/G-domain protein 2;FBS2;FBX6;Fbx6b.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	FBXO6
Gene Fullname	F-box protein 6
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.
Nucleotide accession_num	NM_018438
Protein accession_num	NP_060908
Protein name	F-box only protein 6
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human F-box only protein 6 protein (104-293AA)
Formulation	PBS with, 50% glycerol, pH7.3.

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OACA08868-datasheet.pdf

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Menge: 50 ul

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Lieferung vsl. bis 25.12.2025

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