LEF1 Antibody

ArtNr	OACA09795
Hersteller	AVIVA Systems Biology
Menge	50 ug
Kategorie	Oncology Neuroscience Neural Adhesion Molecules Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Adenocarcinoma Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies By Organ Bladder Cancer Colorectal Cancer Testicular & Prostate Cancer Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, IHC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Purity	>95%
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	LEF-1;lymphoid enhancer-binding factor 1;T cell-specific transcription factor 1-alpha;TCF10;TCF1-alpha;TCF1ALPHA;TCF7L3.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	LEF1
Gene Fullname	lymphoid enhancer binding factor 1
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.
Nucleotide accession_num	NM_001130713
Protein accession_num	NP_001124185
Protein name	Lymphoid enhancer-binding factor 1
Clonality	Polyclonal
Purification	Protein G Purified
Immunogen	Recombinant Human Lymphoid enhancer-binding factor 1 protein (75-216AA)
Formulation	50% Glycerol, 0.01M PBS, PH 7.4

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OACA09795-datasheet.pdf

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Menge: 50 ug

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Lieferung vsl. bis 25.12.2025

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