AAK1 Antibody

ArtNr	OACA10075
Hersteller	AVIVA Systems Biology
Menge	50 ug
Kategorie	Oncology Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Neural Signaling Antibodies By Cell Type Blastoma Carcinoma Hematology Leukemia Lymphoma Melanoma Sarcoma Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, IHC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Purity	>95%
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	adaptor-associated kinase 1;AP2-associated protein kinase 1.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	AAK1
Gene Fullname	AP2 associated kinase 1
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity.
Nucleotide accession_num	NM_014911
Protein accession_num	NP_055726
Protein name	AP2-associated protein kinase 1
Clonality	Polyclonal
Purification	Protein G Purified
Immunogen	Recombinant Human AP2-associated protein kinase 1 protein (274-465AA)
Formulation	50% Glycerol, 0.01M PBS, PH 7.4

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OACA10075-datasheet.pdf

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Menge: 50 ug

lieferbar

Lieferung vsl. bis 25.12.2025

Express-Lieferung: 1 Tage sparen

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