NR5A2 Antibody

ArtNr	OACA10372
Hersteller	AVIVA Systems Biology
Menge	50 ug
Kategorie	Metabolism Cholesterol & Lipid Metabolism Antibodies Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining Other Lipid\Cholesterol Metabolism Modulators
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IHC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Purity	>95%
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Alpha-1-fetoprotein transcription factor;B1-binding factor;b1-binding factor,hepatocyte transcription factor which activates enhancer II of hepatitis B virus;B1F;B1F2;CPF;CYP7A promoter-binding factor;fetoprotein-alpha 1 (AFP) transcription factor;FTF;FTZ-F1;FTZ-F1beta;hB1F-2;Hepatocytic transcription factor;hepatocytic transcription factor hB1F-3;liver nuclear receptor homolog-1 variant 2;Liver receptor homolog 1;LRH1;LRH-1;nuclear receptor subfamily 5 group A member 2.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	NR5A2
Gene Fullname	nuclear receptor subfamily 5 group A member 2
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
Nucleotide accession_num	NM_001276464
Protein accession_num	NP_001263393
Protein name	Nuclear receptor subfamily 5 group A member 2
Clonality	Polyclonal
Purification	Protein G Purified
Immunogen	Recombinant Human Nuclear receptor subfamily 5 group A member 2 protein (182-291AA)
Formulation	50% Glycerol, 0.01M PBS, pH 7.4

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OACA10372-datasheet.pdf

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Menge: 50 ug

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Lieferung vsl. bis 25.12.2025

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